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MINIPRESS (PRAZOSIN HYDROCHLORIDE): PRESCRIBING INFORMATION
Minipress (Prazosin Hydrochloride), a quinazoline derivative, is the first of a new chemical class of antihypertensives. It is the hydrochloride salt of 1-(4-amino-6,7-dimethoxy- 2-quinazolinyl)-4-(2-furoyl) piperazine and its molecular formula C19H21N5O4 x HCl
It is a white, crystalline substance, slightly soluble in water and isotonic saline, and has a molecular weight of 419.87. Each 1 mg capsule of Minipress for oral use contains drug equivalent to 1 mg free base.
Inert ingredients in the formulations are: hard gelatin capsules (which may contain Blue 1, Red 3, Red 28, Red 40, and other inert ingredients); sodium lauryl sulfate; magnesium stearate; sucrose; starch.
Minipress clinical pharmacology
INDICATIONS AND USAGE
Minipress (Prazosin) is indicated in the treatment of hypertension. It can be used alone or in combination with other antihypertensive drugs such as diuretics or beta-adrenergic blocking agents.
Minipress (Prazosin HCl) is contraindicated in patients with known sensitivity to quinazolines, prazosin, or any of the inert ingredients.
DOSAGE AND ADMINISTRATION
Minipress dosage and administration
USE IN SPECIAL POPULATIONS
Minipress use in special populations
Minipress drug interactions
Minipress adverse reactions
Accidental ingestion of at least 50 mg of Minipress (Prazosin) capsules in a two year old child resulted in profound drowsiness and depressed reflexes. No decrease in blood pressure was noted. Recovery was uneventful.
Should overdosage lead to hypotension, support of the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If this measure is inadequate, shock should first be treated with volume expanders. If necessary, vasopressors should then be used. Renal function should be monitored and supported as needed. Laboratory data indicate Prazosin Hydrochloride (Minipress) is not dialysable because it is protein bound.
Minipress 1 mg: white capsules
Minipress 2 mg: pink and white capsules
Minipress 5 mg: blue and white capsules
Manufactured and distributed by Pfizer pharmaceutical company and its divisions.
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