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Buy Minipress (Prazosin Hydrochloride) sympatholytic and antiadrenergic agent
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MINIPRESS (PRAZOSIN HYDROCHLORIDE): DRUG INTERACTIONS

Prazosin HCl (Minipress) has been administered without any adverse drug interaction in limited clinical experience to date with the following: cardiac glycosides– digitalis and digoxin; hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; antigout–allopurinol, colchicine, and probenecid; antiarrhythmics–procainamide, propranolol, and quinidine; and analgesics, antipyretics and anti-inflammatories–propoxyphene, indomethacin, aspirin, and phenylbutazone.

Addition of a diuretic or other antihypertensive agent to Minipress has been shown to cause an additive hypotensive effect. This effect can be minimized by reducing the Minipress capsules dose to 1 to 2 mg three times a day, by introducing additional antihypertensive drugs cautiously, and then by retitrating Minipress (Prazosin) based on clinical response.

Concomitant administration of Minipress (Prazosin HCl) with a phosphodiesterase-5 (PDE-5) inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension.

Drug / Laboratory Test Interactions

In a study on five patients given from 12 to 24 mg of prazosin per day for 10 to 14 days, there was an average increase of 42% in the urinary metabolite of norepinephrine and an average increase in urinary VMA of 17%. Therefore, false positive results may occur in screening tests for pheochromocytoma in patients who are being treated with prazosin. If an elevated VMA is found, prazosin should be discontinued and the patient retested after a month.

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